• br Structural studies of the cyclase catalytic domains br St

  2022-04-13

  

  Structural studies of the cyclase catalytic domains Structural determinants for catalytic activity The structure of the active αβGCcat structure has remained elusive. However, several studies have suggested how specific structural elements are involved in αβGCcat transitioning from the open in

• To further investigate the possible interaction

  2022-04-13

  

  To further investigate the possible interaction of L1 with β1-sGC, a protein-ligand docking experiment was performed. Calculations were carried out with the program GOLD (version 5.2) [18], [34] and performed with the chemPLP scoring function [19], [34]. The ten lowest energy solutions presented a r

• During embryogenesis the expression of

  2022-04-12

  

  During embryogenesis, the expression of zGpr84 was found higher at the cleavage stage and decreased at both blastula and gastrula stages. It indicates that maternal zGpr84 transcripts are present at the cleavage and blastula stages, since zygotic transcripts are not produced before the gastrula stag

• br Activity dependent control of myelination and myelin main

  2022-04-12

  

  Activity-dependent control of myelination and myelin maintenance Oligodendrocytes have intrinsic myelinating capacity and can myelinate fixed Iberiotoxin synthesis in addition to synthetic nanofibers and micropillars [21, 34, 35]. What prevents oligodendrocytes from myelinating dendrites or othe

• As natural ligands of GPR several long chain polyunsaturated

  2022-04-12

  

  As natural ligands of GPR120, several long chain polyunsaturated fatty acids (Lc-PUFAs) have been demonstrated to modulate the 3T3-L1 adipogenic differentiation. However, the effects of the Lc-PUFAs are inconclusive. DHA is shown to inhibit, promote or even not affect the differentiation of preadipo

• br Material and methods br Results Consistent with our

  2022-04-12

  

  Material and methods Results Consistent with our previous study, SR-SIM and confocal microscopy showed a large number of IBA1-expressing chemicals from this source in all parts of the human cochleae (Fig. 1). IBA1, the microglial and macrophage-specific calcium-binding protein, is involved in

• Alpha synuclein AS is a protein located in presynaptic

  2022-04-12

  

  Alpha synuclein (AS) is a protein located in presynaptic terminals of neurons that functions in recycling and storage of neurotransmitters [17]. Under conditions of inflammation and oxidative stress, AS proteins misfold and accumulate into psoralen sale [81], [90]. The aggregates of misfolded AS oli

• br Methods br Results br Discussion Among three main signali

  2022-04-12

  

  Methods Results Discussion Among three main signaling pathways activated by bFGF, the MAPK pathway was found to be involved in the upregulation of GR levels. So far, there have been a few candidates that could connect activated ERK to the upregulation of GR. One likely candidate is the zinc

• br Hedgehog HH signaling plays an important role both during

  2022-04-12

  

  Hedgehog (HH) signaling plays an important role both during embryonic development and adult life. It is involved in the regulation of cell differentiation, cell proliferation and tissue polarity, as well as in the maintenance of stem cells, tissue repair, and regeneration (, ). Three ligands, Indi

• According to the aforementioned preclinical and clinical dat

  2022-04-12

  

  According to the aforementioned preclinical and clinical data, GHS-R1a blockade appears to be a potential pharmacological approach to treat AUD. Given that GHS-R1a has high constitutive (ligand-independent) activity, inverse agonism of the receptor may exert more potent and desirable effects than pu

• Our own search towards aryl imidazole derived GSMs

  2022-04-12

  

  Our own search towards aryl-imidazole derived GSMs led to the discovery of the benzimidazole derivative (). It is one of the most potent GSMs to date, suffering however from sub-optimal drug-like properties. More recently, we have described the design and synthesis of bicyclic triazolo-derivatives,

• Determination of enzyme activity differs from other analytic

  2022-04-12

  

  Determination of enzyme activity differs from other analytical procedures. In this GS-9137 case, instead of enzyme concentration, a substrate depletion or product accumulation should be monitored. Such approach allows calculating activity basis of calibration curves performed for enzymatic reaction

• In single channel studies Zn primarily

  2022-04-12

  

  In single channel studies, Zn2+ primarily inhibits GABA-A receptors through the reduction of channel opening probability (Smart, 1992, Smart et al., 1994). In slice recordings, Zn2+ significantly reduces phasic mIPSC event amplitude and kinetics, as well as desensitization kinetics (Barberis et al.,

• cell tak br Competing interests br Authors contributions

  2022-04-12

  

  Competing interests Authors contributions Transparency document Introduction Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver diseases ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), which may further progress to liver cirrhosis and liver carcinoma

• Acknowledgments This work was supported

  2022-04-12

  

  Acknowledgments This work was supported by the Natural Science Foundation of China (Nos. 21602254, 81603194), the Natural Science Foundation of Jiangsu province, China (BK20160767) and National Found for Fostering Talents of Basic Science (NFFTBS, J1310032). Introduction Glucocorticoids (GC) pl

15883 records 447/1059 page Previous Next First page 上5页 446447448449450 下5页 Last page