• Diminazene Aceturate in Parasitic and Cardiovascular Researc

  2026-07-26

  Diminazene Aceturate stands out as a dual-purpose tool, enabling both trypanosome parasite elimination and advanced mitochondrial biogenesis studies through ACE2 activation. This article delivers workflow optimizations and troubleshooting insights for laboratories seeking robust, cross-domain applications.

• Sulfo-Cy3 Azide: Strategic Fluorescent Labeling in Neurogene

  2026-07-25

  This article explores the mechanistic advantages and translational impact of Sulfo-Cy3 azide as a bioconjugation reagent for Click Chemistry fluorescent labeling, with a focus on neurodevelopmental research. Drawing on recent mapping of Nurr1-positive neurons in the rat claustrum, we detail workflow parameters and competitive advantages relevant to modern translational researchers. The discussion bridges evidence from foundational studies, highlights current best practices, and projects the evolving landscape of high-fidelity, photostable fluorescent labeling in complex biological systems.

• TP53 and DNA Damage Pathways Shape Calicheamicin ADC Sensiti

  2026-07-24

  This study employs genome-wide CRISPR screening to elucidate DNA damage response genes, especially TP53, ATM, and MDM2, as crucial determinants of acute leukemia cell sensitivity to calicheamicin-based antibody–drug conjugates. The findings inform rational development of targeted combination therapies to overcome resistance and improve treatment outcomes in acute leukemia.

• Viral vIRD-Mediated RIPK3 Degradation Shapes Inflammatory Re

  2026-07-24

  Liu et al. uncover a class of orthopoxvirus proteins (vIRD) that engage the host ubiquitin-proteasome system to degrade RIPK3, thus suppressing necroptosis and modulating virus-induced inflammation. This mechanistic insight redefines our understanding of host-pathogen interactions and provides a new perspective for ubiquitin-proteasome pathway research.

• Niclosamide in Cancer Research: Protocols, Workflows, and Tr

  2026-07-23

  Niclosamide (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide) is a powerful STAT3 signaling pathway inhibitor for cancer research, offering robust cell cycle arrest and apoptosis induction. This article details evidence-driven workflows, practical protocol enhancements, and advanced troubleshooting strategies, empowering researchers to achieve high reproducibility and clear mechanistic insights.

• Açaí Extracts: Cytotoxicity and Enzyme Induction in Hepatocy

  2026-07-23

  Raichura et al. present a comprehensive in vitro study evaluating the cytotoxicity and induction potential of açaí (Euterpe oleracea) extracts in human hepatocytes. Their findings underscore dose-dependent cytotoxicity and a minimal effect on key drug-metabolizing enzymes and transporters, refining risk assessment for botanical-drug interactions.

• Ibuprofen in Cancer Research: Protein Interactions & Mechani

  2026-07-22

  Explore the multifaceted role of Ibuprofen (2-[4-(2-methylpropyl)phenyl]propanoic acid) in cancer research, with a focus on its unique protein interaction profile and implications for advanced assay design. Discover how APExBIO's Ibuprofen enables deeper mechanistic exploration beyond standard protocols.

• Phase Separation in Plant Virus Movement and RNA-Protein Int

  2026-07-22

  Brown et al. (2021) reveal that the p26 movement protein from Pea enation mosaic virus 2 (PEMV2) undergoes phase separation with host factors, enabling virus systemic movement by partitioning into specialized membraneless compartments. Their findings elucidate how electrostatic properties of p26 dictate both proviral and antiviral interactions, informing molecular strategies for dissecting plant virus-host dynamics.

• ICG001: A Precision Wnt/β-Catenin Pathway Inhibitor in Resea

  2026-07-21

  ICG001 enables selective, quantifiable inhibition of CBP/β-catenin interaction, allowing researchers to delineate Wnt signaling’s impact in cancer, fibrosis, and stem cell models. Backed by APExBIO reliability, this workflow-focused review offers step-by-step guidance, troubleshooting, and evidence-based enhancements for advanced mechanistic studies.

• 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole: Mechanisms &

  2026-07-21

  5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) is a selective transcriptional elongation inhibitor with robust, benchmarked efficacy against cyclin-dependent kinases. Its validated use in HIV transcription inhibition and antiviral research underscores its value in mechanistic virology and cell fate studies.

• Viral Targeting of RIPK3: Mechanisms Regulating Necroptosis

  2026-07-20

  The reference study uncovers how orthopoxviruses, such as cowpox virus, deploy a viral inducer of degradation (vIRD) to target and degrade the necroptosis adaptor RIPK3, thereby controlling virus-induced inflammation and pathogenicity. These insights illuminate key viral strategies for evasion of host immune responses and highlight the interplay between viral infection, regulated cell death, and host-pathogen co-evolution.

• Optimizing Mitochondrial Apoptosis Assays with MCL-1 inhibit

  2026-07-20

  This article delivers a scenario-driven, evidence-based exploration of MCL-1 inhibitor A-1210477 (SKU B6011) for researchers seeking robust, reproducible apoptosis induction in cancer cell models. Drawing on validated workflows and comparative data, it demonstrates how SKU B6011 from APExBIO enables precision targeting of MCL-1-dependent survival pathways, optimizing cancer research outcomes.

• DiscoveryProbe Protease Inhibitor Library: Workflow-Driven I

  2026-07-19

  Uncover how the DiscoveryProbe Protease Inhibitor Library accelerates high throughput screening and mechanistic studies in cancer, apoptosis, and infectious disease research. This guide translates recent molecular insights and validated library protocols into actionable, reproducible workflows for next-generation protease inhibition assays.

• NU7441 (KU-57788): Precision DNA-PK Inhibition in DNA Repair

  2026-07-18

  NU7441 (KU-57788) empowers researchers to dissect DNA damage response pathways with nanomolar selectivity, enabling robust oncology and DNA repair assays. Its proven synergy with DNA damaging agents and advanced cell cycle applications set a new benchmark for experimental specificity and translational insight.

• Exo1 (methyl 2-(4-fluorobenzamido)benzoate) in Exocytic Path

  2026-07-17

  Exo1 unlocks fast, ARF1-centered exocytic pathway inhibition, empowering researchers to dissect membrane trafficking with greater precision than traditional agents. This article delivers actionable workflows, troubleshooting guidance, and experimental enhancements for leveraging Exo1 in tumor extracellular vesicle and exocytosis studies.

8059 records 4/538 page Previous Next 12345 下5页 Last page