• The repurposing of well characterized and well tolerated

  2022-07-22

  

  The repurposing of well-characterized and well-tolerated drugs in order to treat illnesses for which they were not originally intended has emerged as an attractive alternative to a long and costly process of drug development. Repositioning antihistaminergic ligands seems a promising idea given that

• Successful immune escape will be then followed

  2022-07-22

  

  Successful immune escape will be then followed by cancer development, along with which immunocytes infiltration occurs. While some immunocytes are born to sweep away the malignancy, others aim to neutralize the lethality and sustain immune anergy and tolerance [59,60]. And the latter one is well rep

• In vitro studies suggest that the increase in Hx activity

  2022-07-22

  

  In vitro studies suggest that the increase in Hx activity seen in normal pregnancy may contribute to the down-regulation of the vascular expression of Angiotensin II receptor 1 thereby promoting a relaxed and dilated maternal vascular bed [25]. It has further been suggested that the decreased Hx act

• Introduction Non alcoholic hepatic steatosis is characterize

  2022-07-21

  

  Introduction Non-alcoholic hepatic steatosis is characterized by the presence of steatosis in hepatocytes [1], which leads to the development of fatty liver [2]. It is strongly associated with obesity, insulin resistance, and type II diabetes [3]. They are major risk factors of non-alcoholic hepati

• br GPR is a class

  2022-07-21

  

  GPR119 is a class A GPCR expressed on pancreatic β-cells and certain enteroendocrine Bcl Family Set I which upon activation with an agonist, increases insulin secretion in response to rising glucose levels. Mechanistically, this insulinotropic effect is bifurcated involving both GPR119-mediated β

• The PCR based analysis of TRECs in general is laborious

  2022-07-21

  

  The PCR-based analysis of TRECs in general is laborious, technically challenging and comparison of results obtained in different laboratories is difficult as different normalization standards exist. Moreover the analysis is restricted to analysis of cell populations (Douek et al., 1998; Jamieson et

• Like other RNA viruses HCV also exhibits a high

  2022-07-21

  

  Like other RNA viruses HCV also exhibits a high degree of genetic diversity, creating a major challenge for the development of both HCV vaccines and pan-genotypic therapeutics (Timm and Roggendorf, 2007). The virus has a total of seven genotypes, with >50 subtypes and millions of quasispecies (Cuype

• Given and a module N

  2022-07-21

  

  Given and a -module N, we put The right hand side makes sense because we regard g as an Hydrocortisone of and meanwhile . It is also a skew group ring, identified with via the following equation It follows that becomes a -module, with Analogous to the situation of group representations, the underlyi

• The precise mechanisms of action of PBA are as

  2022-07-21

  

  The precise mechanisms of action of 4-PBA are as yet ambiguous. Its capacity as a chemical chaperone has been thoroughly documented for the ABC transporter family in particular (Prulière-Escabasse et al., 2007; Iram and Cole, 2014; Gordo-Gilart et al., 2016; Pomozi et al., 2017). 4-PBA has been clas

• topoisomerase inhibitors br Ligand binding free energies In

  2022-07-21

  

  Ligand-binding free energies In order to compute the absolute free topoisomerase inhibitors associated with binding a ligand to a flexible iGluR LBD, a theory that accounts for all the principal thermodynamic contributions from ligand docking and LBD closure had to be developed. This was accompl

• br Acknowledgements br Introduction Benzodiazepine BZ

  2022-07-21

  

  Acknowledgements Introduction Benzodiazepine (BZ) treatment is widely used for quick and efficient anxiolytic and sedative responses. However, when the use is extended to longer periods, adverse effects emerge. These include tolerance to the initial drug effect, dependence as revealed by withd

• br Acknowledgments The financial support from the National N

  2022-07-21

  

  Acknowledgments The financial support from the National Natural Science Foundation of China (Nos. 31460422 and 31060210), the Natural Science Foundation of Jiangxi Province, China (20171BAB204029 and 20143ACB20006), the Project of Science and Technology of Jiangxi Provincial Education Department,

• Nuclear export of GK has been reported to

  2022-07-21

  

  Nuclear export of GK has been reported to be dependent on a GK nuclear export signal (NES), mapped to residues 300–310 (Shiota et al., 1999). The assignment of a nuclear export signal common to both the liver and pancreatic GK isoform sequence suggests a possible reversible translocation of GK acros

• Acknowledgments br Introduction Type diabetes mellitus T DM

  2022-07-21

  

  Acknowledgments Introduction Type 2 diabetes mellitus (T2DM) is caused by relative insulin deficiency or insulin resistance in peripheral tissues. The clinical management of T2DM is achieved by controlling blood glucose levels. Current therapies available for treatment of T2DM include biguanides

• Gap junctions mediate electrical coupling between cells by

  2022-07-21

  

  Gap junctions mediate electrical coupling between cells by conducting direct ionic currents and thereby modulate their electrical activity (Hormuzdi et al., 2004). In the nervous system, electrical coupling organizes network activity by amplifying and synchronizing neuronal firing (Galarreta and Hes

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