• DNA Damage Biomarkers Improve Micronucleus Assays

  2026-08-13

  Avlasevich and colleagues combined flow-cytometric micronucleus scoring with DNA damage response and cytotoxicity biomarkers to clarify genotoxic mode of action. Across reference chemicals tested with and without metabolic activation, requiring concordant micronucleus and MultiFlow responses substantially improved specificity while preserving sensitivity.

• Optimized hiPSC-Derived Platelet Differentiation

  2026-08-12

  This 2026 study presents an optimized differentiation scheme for generating functional megakaryocytes and platelets from human induced pluripotent stem cells. By increasing embryoid body input, introducing human platelet lysate and small-molecule substitutions, and promoting megakaryocyte maturation, the protocol improves yield, shortens production time, and lowers reported costs.

• Acifran as a Receptor-Resolved Lipid Probe

  2026-08-12

  Acifran is a mechanistically informative probe for HCAR2/HCAR3 signaling and lipid metabolism research. This article translates recent cryo-EM findings into receptor-paired assay strategies, compound-handling guidance, and more rigorous interpretation of lipid signaling data.

• Thiazovivin: ROCK Inhibitor Workflow Guide

  2026-08-11

  Thiazovivin (SKU A5506) is a ROCK inhibitor for research workflows involving fibroblast reprogramming and human embryonic stem cell recovery after trypsinization. It should be optimized as a research reagent rather than treated as a universal or clinical protocol component, because the supplied dossier does not define a validated working concentration or exposure schedule.

• Caspase-3–NDUFS1 Axis in Trichothecene ROS

  2026-08-11

  This preprint identifies a caspase-3/NDUFS1 pathway that links apoptotic signaling to mitochondrial complex I disruption and shows how ERO1α-derived endoplasmic reticulum stress may reinforce trichothecene-induced ROS accumulation. The findings provide a mechanistic framework for studying DON- and T-2 toxin-associated liver injury, while requiring independent validation because the study has not yet been peer reviewed.

• Sulfonamide Inhibition of hPON1: Study Insights

  2026-08-10

  A 2017 study systematically compared six sulfonamides as inhibitors of purified human serum paraoxonase 1 (hPON1), identifying distinct noncompetitive, mixed-type, and competitive inhibition patterns. Sulfisomidine showed mixed-type inhibition, providing a useful mechanistic basis for enzyme kinetics and for interpreting how sulfonamide chemistry may intersect with oxidative and lipid-related biology.

• Ceftolozane-Tazobactam for Nosocomial Pneumonia

  2026-08-09

  The reference review explains how ceftolozane-tazobactam combines anti-pseudomonal cephalosporin activity with beta-lactamase inhibition to address difficult nosocomial pneumonia pathogens. Its synthesis of structural, susceptibility, pharmacokinetic-pharmacodynamic, and clinical evidence supports targeted use against resistant Pseudomonas aeruginosa while clarifying important limits involving ESBLs, carbapenemases, and post-hoc clinical analyses.

• SP2509 for Reliable AML Epigenetics

  2026-08-08

  SP2509 (SKU B4894) offers a data-grounded approach to LSD1 inhibition in acute myeloid leukemia research, with nanomolar biochemical potency, defined solubility, and practical storage guidance. This scenario-based guide helps researchers connect assay design, compound handling, mechanistic readouts, and vendor evaluation without overstating cellular or translational conclusions.

• Streptavidin-Cy3 for Biotin Detection and IF

  2026-08-07

  Streptavidin-Cy3 is a fluorescent streptavidin reagent for high-affinity detection of biotinylated antibodies, proteins, nucleic acids, and other biomolecules. This streptavidin cy3 conjugate combines four biotin-binding sites per tetramer with Cy3 fluorescence centered at 554 nm excitation and 568 nm emission, supporting IHC, IF, ISH, and flow cytometry workflows.

• Caspase 3/7 Regulate Autophagy and DNA Damage Response in Br

  2026-08-07

  This study uncovers a non-apoptotic role for caspase 3 and 7 in promoting cytoprotective autophagy and DNA damage signaling under non-lethal stress in human breast cancer cells. The findings refine understanding of cell stress adaptation and suggest new directions for therapeutic targeting, particularly in relation to BRCA1-deficient tumors.

• β-Pseudouridine: Optimizing RNA Modification for Translation

  2026-08-06

  β-Pseudouridine, the C-glycoside isomer of uridine, is transforming the design of next-generation RNA vaccines and epitranscriptomic studies by stabilizing RNA structures and enhancing translational fidelity. This guide delivers practical workflows, troubleshooting strategies, and actionable insights directly informed by the latest comparative immunogenicity research.

• Moxifloxacin in Research: Mechanistic Depth and Metabolic Im

  2026-08-06

  Explore the advanced research applications of Moxifloxacin, a leading fluoroquinolone antibiotic, with a focus on mechanistic depth and metabolic effects. This article offers unique insight into protocol optimization and the nuanced interplay between gyrase inhibition, cytotoxicity, and metabolic responses.

• CHK1 Inhibition in Breast Cancer: ER/PR Status Drives Therap

  2026-08-05

  This study demonstrates that the effectiveness of CHK1 inhibition in breast cancer is intricately dependent on estrogen and progesterone receptor status, influencing both chemosensitivity and single-agent antitumor activity. These findings refine the molecular stratification of breast cancer therapy and suggest new directions for targeted intervention.

• Canagliflozin: SGLT2 Inhibitor Workflows in Kidney Disease M

  2026-08-05

  Harness Canagliflozin’s unique ability to remodel renal mitochondria for advanced diabetes and kidney research. This guide translates novel findings into practical protocols, troubleshooting, and workflow optimization—empowering researchers to unlock new dimensions in metabolic disease modeling.

• MVC Activates RhoA/ROCK1 Pathway to Disrupt Tight Junctions

  2026-08-04

  This study uncovers how the Minute Virus of Canines (MVC) hijacks the RhoA/ROCK1/MLC2 signaling pathway, leading to tight junction dissociation and facilitating infection via occludin exposure. The findings highlight new molecular targets for antiviral strategies and provide a mechanistic bridge between RhoA signaling, tight junction regulation, and viral pathogenesis.

8059 records 2/538 page Previous Next 12345 下5页 Last page