• Potentiation of the HDAC Pin signaling module by

  2018-10-23

  

  Potentiation of the HDAC6-Pin1 signaling module by GRK2 in specific breast cancer cells could be envisaged as an bax pathway to enhanced activity of different tumor-promoting cascades that would trigger a self-perpetuating positive feedback cycle promoting cell proliferation and increased survival.

• IL induces STAT activation in myeloid

  2018-10-23

  

  IL-10 induces STAT3 activation in myeloid adiponectin receptor resulting in the regulation of proinflammatory gene expression in these cells, and myeloid cell specific deletion of STAT3 develop colitis in a phenomena similar to IL-10 deficient mice (Kobayashi et al., 2003), suggesting that STAT3 is

• Accumulating scientific evidence suggests different profiles

  2018-10-23

  

  Accumulating scientific evidence suggests different profiles of each IgG subclass in protection against pathogens. Human IgG1 is the most dominant subclass in human sera and generally plays an important role in the protection against a variety of viral infections. In addition to inactivation and/or

• Although still incurable the survival rate of MM

  2018-10-23

  

  Although still incurable, the survival rate of MM, the second most common hematologic malignancy (Siegel et al., 2014), has improved mainly due to the development of new and highly effective agents, such as immunomodulators and proteasome inhibitors (Kumar et al., 2012). CFZ is an irreversible epoxy

• These characteristics of Tat secretion are remarkably overla

  2018-10-23

  

  These characteristics of Tat secretion are remarkably overlapping with those of cellular FGF-2, which is also sensitive to ouabain and involves binding of the factor to the Na+,K+-ATPase (Dahl et al., 2000; Florkiewicz et al., 1998; Smith et al., 2001; Trudel et al., 2000; Zeitler et al., 2015), whi

• Zinc is an essential nutrient for microbial

  2018-10-23

  

  Zinc is an essential nutrient for microbial growth, but can be toxic in excess (Blencowe and Morby, 2003; Coleman, 1998). The delicate balance between zinc sufficiency and toxicity is maintained by bacterial metal homeostasis systems (Klaus, 2005; Moore and Helmann, 2005). The GAS metalloregulator,

• br Acknowledgements br Introduction Hepatocellular carcinoma

  2018-10-23

  

  Acknowledgements Introduction Hepatocellular carcinoma (HCC), the second leading cause of cancer deaths worldwide (Torre et al., 2015), arises in people with chronic liver disorders and inflammation. Most patients are not suitable for hepatic resection or transplantation. To treat these patien

• Antigen Rv is a secretory antigen and a

  2018-10-23

  

  Antigen Rv0577 is a secretory antigen and a virulence factor associated with the replication of M. tuberculosis. The antigen is an agonist of Toll-like receptor 2 (TLR2) and can promote maturation of dendritic cells (Byun et al., 2012). Rv2875 encodes a cell membrane-associated antigen, MPT70, of M.

• Antigen Rv is a secretory antigen and a

  2018-10-23

  

  Antigen Rv0577 is a secretory antigen and a virulence factor associated with the replication of M. tuberculosis. The antigen is an agonist of Toll-like receptor 2 (TLR2) and can promote maturation of dendritic cells (Byun et al., 2012). Rv2875 encodes a cell membrane-associated antigen, MPT70, of M.

• Data Data on sugarbeet root unigenes that were differentiall

  2018-10-23

  

  Data Data on sugarbeet root unigenes that were differentially expressed due to a postharvest jasmonic acid (JA) treatment are presented. Data identify unigenes that were differentially expressed 2 and 60 d after JA treatment. Data include the logarithm of the fold change in expression due to JA tre

• br Introduction A balance sheet provides vital

  2018-10-22

  

  Introduction A balance sheet provides vital information regarding a bank’s financial position at any given point of time. The asset side includes loans forwarded to borrowers while the liabilities side, among other things, shows deposits made by customers (Diamond & Rajan, 1999). Banks not only s

• This study deviates from other studies in a

  2018-10-22

  

  This study deviates from other studies in a number of ways. Firstly, we study institutional quality along with other variables specifically financial factors that determine corporate investment. Our choice of Nigeria is based on the fact that the country is experiencing high rate of deficiencies in

• To estimate the model we use static and dynamic estimation

  2018-10-22

  

  To estimate the model, we use static and dynamic estimation techniques. The static estimation is the fixed effect OLS estimator to capture bank-specific differences while the dynamic estimation is the GMM estimator to capture dynamic adjustments to bank profitability. We consider dynamic adjustments

• Another challenge for architects facility managers and inter

  2018-10-22

  

  Another challenge for architects, facility managers, and interior designer is integrating a design specification that relates to the sense of home into a design of nursing homes, which is often based on dementia-friendly design models. Zeisel (2005), among other scholars, stated that several dementi

• French Jesuits published the handbook dated

  2018-10-22

  

  French Jesuits published the handbook, dated 19 March 1926 (preface), in this context of polarization between two schools, the old one and the new one, within the China mission. The handbook’s preface opens with a statement: “This brochure is not made for cathedral builders. This is not even an essa

15871 records 1056/1059 page Previous Next First page 上5页 1056105710581059