• In recent years several groups have attempted

  2018-10-23

  

  In recent years several groups have attempted to identify specific signatures to distinguish between tuberculosis and sarcoidosis using transcriptomics or gene expression profilings (Koth et al., 2011; Maertzdorf et al., 2012; Berry et al., 2010). Yet, most of these methods led to the discovery of a

• In the clinic preconditioning is typically ascribed

  2018-10-23

  

  In the clinic, ‘preconditioning’ is typically ascribed to a transient mild stress followed by a recovery interval (Nishio et al., 2000; Stetler et al., 2014). Here we have applied this ahr inhibitor term in its broadest sense — i.e., a subtoxic cellular stress that can lead to a protective state (S

• br Introduction The Middle East respiratory syndrome coronav

  2018-10-23

  

  Introduction The Middle East respiratory syndrome coronavirus (MERS-CoV) is the only lineage C betacoronavirus known to infect humans (Annan et al., 2013; Anthony et al., 2013; van Boheemen et al., 2012). Similarly to severe acute respiratory syndrome coronavirus (SARS-CoV), MERS-CoV infection ca

• The study by Kl ppel and colleagues

  2018-10-23

  

  The study by Klöppel and colleagues can decisively shape future functional neuroimaging research in HD and other neurodegenerative conditions, but we believe that there is much more to learn from this study. The rationale and design should also motivate psychiatric research, where there is still an

• br Funding and Role of Funder br Conflicts

  2018-10-23

  

  Funding and Role of Funder Conflicts of Interest Author Contributions Acknowledgements This work was supported by the Intramural Research Program, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health. We thank Dr. Oksana Gavrilova for her excell

• Finally we searched the Allele Frequencies in Worldwide Popu

  2018-10-23

  

  Finally, we searched the “Allele*Frequencies in Worldwide Populations” (http://www.allelefrequencies.net/) website for known haplotypes related to the 6 discriminating alleles, within the 3 databases that we used. Haplotype information was available only for the SF database, as shown in Table 5. It

• Recent attention has focused on the role

  2018-10-23

  

  Recent attention has focused on the role of vitamin D in infectious (de Haan et al., 2014) and autoimmune disease, including tuberculosis (Yang et al., 2013). In resource-limited settings, which have the largest burden of advanced HIV disease, mycobacteria are the most common pathogen involved in th

• br Introduction Type diabetes mellitus T DM and Alzheimer

  2018-10-23

  

  Introduction Type 2 diabetes mellitus (T2DM) and Alzheimer\'s disease (AD) are the most common age-associated disorders and the prevalence of the diseases is increasing with population aging (Biessels et al., 2008; Exalto et al., 2012; Stumvoll et al., 2005; Umegaki, 2014). The epidemiological st

• DM transcriptomic profiles identified differentially express

  2018-10-23

  

  DM2 transcriptomic profiles identified 14 differentially expressed genes, which possibly contribute to the onset of myalgias in DM2 patients. One of the identified differentially expressed genes encodes monoamine oxidase A (MAOA). Polymorphisms in the MAOA gene have been proposed to segregate with l

• br Materials and methods br Results br

  2018-10-23

  

  Materials and methods Results Discussion Isoniazid (INH) is together with rifampicin the corner stone of the TB treatment. It has been administrated to >40 million people saving millions of lives. Its outstanding cidal effect rapidly blocks bacterial spread and significantly improves patien

• Structure based drug design targeting the well defined

  2018-10-23

  

  Structure-based drug design targeting the well-defined interface (Cherepanov et al., 2005) between the IBD and the HIV-1 IN catalytic core resulted in the development of 2-(quinolin-3-yl)acetic Forskolin derivatives that inhibit HIV-1 replication (Christ et al., 2010). This novel class of antiviral

• Using a wide array of histological and electrophysiological

  2018-10-23

  

  Using a wide array of histological and electrophysiological experimental approaches, these data clearly support a mechanistic role of neuronal nadph oxidase in the intrinsic epileptogenicity of human HH and strenghten the cellular model in which HH neuron clusters of spontaneously firing interneuro

• We also found that q does not

  2018-10-23

  

  We also found that 1q+ does not show preference in evolutionary timing—it may occur as an early or late event—which suggests that its oncogenic effect is independent of other genetic changes. Therefore, we suspect that 1q+ may have a similar effect on WT outcome regardless of whether it is homogeneo

• br Grant Support This work was

  2018-10-23

  

  Grant Support This work was supported by a research grant from the National Science Council, Taiwan and the Institute of Biomedical Sciences, Academia Sinica (IBMS-CRC103-P02). Conflicts of Interest Author Contributions Introduction Because of late presentation and chemotherapy resistan

• In this background it can

  2018-10-23

  

  In this background, it AMG-517 can be foreseen that individuals could do a diagnostic neuropsychological evaluation via the use of a videoconference approach. However, a few considerations and challenges on the use of technology must be addressed. Foremost, the privacy, security and confidentiality

15871 records 1055/1059 page Previous Next First page 上5页 10511052105310541055 下5页 Last page