Taken together we here show

2018-10-20

Taken together, we here show that the recently identified marker SPOT14 labels low-proliferating NSPCs in the hippocampus that react dynamically to positive and negative neurogenic stimuli in vivo. These data further validate the usefulness of this restrictive and functionally relevant marker to ana

br Results and Discussion Using the neurosphere protocol Pic

2018-10-20

Results and Discussion Using the neurosphere protocol (Piccirillo et al., 2009), we established stable patient-derived cell cultures from dissociated tumor tissue from 12 cases of primary GBM (Table S1 available online). In order to exclude the possibility of in vitro aberrations and culture sele

However before application in a clinical context

2018-10-20

However before application in a clinical context, a number of issues still need to be considered. Indeed, SSC transplantation in cancer patients requires techniques to exclude cancer cell contamination, because implantation of as few as 20 leukemic ck2 inhibitor can result in cancer relapse (Jahnuka

melanocortin 1 receptor br Experimental Procedures br Acknow

2018-10-20

Experimental Procedures Acknowledgments Introduction Germ melanocortin 1 receptor are the only cells that continue to be reprogrammed throughout their lifetime in order to transfer genetic information to subsequent generations (Sasaki and Matsui, 2008). Germ cells have unique characteristi

Several possibilities could explain the aberrant expression

2018-10-20

Several possibilities could explain the aberrant expression of ATM in Q3SC. Exon skipping has been observed in several genes (Dutertre et al., 2010; Nevo et al., 2012) and is believed to be influenced by ATM function (Tresini et al., 2015). By amplifying cDNA with PCR primers targeting sites outside

For live cell imaging we

2018-10-20

For live-cell imaging, we established a 96-well plate-based screening assay to assess expression of the pluripotency-associated surface marker TRA-1-60, a more reliable and specific marker for predicting successful reprogramming and iPS cell derivation than other markers including AP (Mali et al., 2

EWS FLI a widely recognized fusion oncogene for Ewing

2018-10-20

EWS-FLI1, a widely recognized fusion oncogene for Ewing sarcomas, is generated by the chromosomal translocation of t(11;22) (q24;q12), which consists of the N-terminal transactivator domain of the EWS gene and the C-terminal ETS DNA binding domain of the FLI1 gene. The resulting EWS-FLI1 fusion prot

acetylcholine receptors MYC is not a pluripotency

2018-10-20

MYC is not a pluripotency factor, but it substantially improves reprogramming dynamics, primarily because MYC accelerates cell proliferation (Sabo et al., 2014; Walz et al., 2014), providing an opportunity for the somatic genome to gradually reshape its epigenetic landscape. MYC is critical at an ea

Telomeres are repetitive DNA structures at the

2018-10-20

Telomeres are repetitive DNA structures at the chromosome ends that safeguard them from DNA repair and degradation activities. This protective function requires a proper telomere length and the binding of a six-protein complex known as shelterin, including TRF1, which is essential for telomere prote

Hello world!

2018-07-29